Skip to main content

What is Tryptophan? Explaining the Sleepy Amino Acid

Man in bed with sleep mask.
Cavan Images / Adobe Stock

Whether you’re on the dark meat or white meat side of the debate, if you’ve ever found yourself struggling to keep your eyes open while the conversation around the Thanksgiving table stretches long into the evening, you’re probably familiar with the sleepiness that can ensue from a big plate of roasted turkey. It’s not just fatigue from holiday travel or preparing a big meal—turkey is actually rich in a specific amino acid called tryptophan. Tryptophan foods can cause sleepiness and leave you feeling ready for a post-meal nap.

But what exactly is tryptophan and how does it work? And is turkey the only food that contains tryptophan? Keep scrolling to learn more about the mysterious, sleepy amino acid: tryptophan.

Recommended Videos

What Is Tryptophan?

Tryptophan molecule on a white background.
Image used with permission by copyright holder

Our bodies break down all proteins found in food into 20 different amino acids, whether the protein comes from meat, beans, dairy, eggs, fish, vegetables, etc. These amino acids are considered the building blocks of protein, meaning that our bodies use amino acids to manufacture all the various structural and functional proteins in the body. Much like letters in the alphabet, by stringing together different combinations of these amino acids “letters,” our bodies are able to make the hundreds of different combinations of amino acids that constitute the wide variety of proteins we need to function.

While we often just think of proteins forming structures like our muscles, they are involved in nearly every structure and function of the body in some way, from forming DNA to producing energy, to creating neurotransmitters to fueling white blood cells.

Tryptophan is one of the 20 amino acids used by the human body to build proteins and carry out key physiological functions. It is an essential amino acid, which means that the body cannot synthesize it; it must be consumed in the diet. Studies have found that tryptophan is involved in the production of niacin, a B vitamin, and tryptophan can be converted into 5-hydroxytryptophan (5-HTP), a molecule used to synthesize serotonin—a neurotransmitter involved in mood and sleep—and melatonin, a hormone involved in regulating circadian rhythms and promoting sleep.

How Does Tryptophan Impact Sleep?

Studies have shown that increasing levels of tryptophan increase serotonin and melatonin and improve sleep. Because serotonin can reduce anxiety and melatonin can help regulate sleep-wake cycles, consuming tryptophan may promote sleepiness.

Foods High In Tryptophan

Selection food in tryptophan.
Image used with permission by copyright holder

While turkey may be the poster child for food sources of tryptophan, there are plenty of other foods high in tryptophan. As tryptophan is an amino acid, most tryptophan-rich foods are proteins.

  • Milk
  • Poultry
  • Pork
  • Salmon
  • Shrimp
  • Crab
  • Yogurt
  • Cheese
  • Oatmeal
  • Tofu and Edamame
  • Eggs
  • Squash and Pumpkin Seeds
  • Peanut Butter
  • Sweet Potatoes
  • Lean Beef

How Much Tryptophan Do You Need?

The recommended daily intake of tryptophan is 4 mg per kilogram of body weight. For example, someone weighing 85 kg (187 pounds) should aim for 340 mg of tryptophan per day.

Low levels of tryptophan have been linked to depression and low mood, aggressive behavior, learning and memory impairment, and sleep disturbances. These outcomes are attributed to reduced levels of serotonin and melatonin due to a paucity of 5-HTP. In other words, when levels of tryptophan are low, not enough tryptophan is available to be converted to 5-HTP, which then means that not enough serotonin and melatonin are produced.

Amber Sayer
Former Digital Trends Contributor
Amber Sayer is a fitness, nutrition, and wellness writer and editor, and was previously a Fitness Editor at Byrdie. She…
What foods are high in iron? These staples will help you live a healthier life
Add these high-iron foods to your shopping list today
Ribeye caps topped with garlic and herbs cooked in a cast iron pan over charcoal.

What foods are high in iron? We all know that iron is important for a healthy, balanced diet, but did you know you can find two different kinds of iron in food: heme and non-heme. Your body can absorb iron from heme (animal-based) food better than from non-heme (plant-based) food sources. Where can you find heme food sources? Read on to find out about foods high in iron.

If you eat a plant-based diet, you’ll get a lot of non-heme types of iron. As a result, your body might need a bit of help to absorb it properly. Sometimes vitamin C can aid with the absorption of plant-based kinds of iron. Regularly consume both plant and animal-based sources of iron to get the best of both for your body. 
What is iron?

Read more
What is the healthiest fruit? 5 items you should be eating daily
Fruit Salad

Consuming a variety of fruits can contribute to a healthy gut microbiome and reduce the risk of chronic diseases. But do you know which are the healthiest fruits for you? Let's look at how many and what type of fruits you should be eating for optimal health. 

What is the healthiest fruit?
The healthiest fruit is not a single fruit but rather a variety of fruits that offer a range of nutritional benefits. According to the American Heart Association, adults are recommended to consume 4-5 servings of fruits and vegetables per day.

Read more
Here are the benefits of taking vitamin D supplements – what you should know
Find out if you're getting enough Vitamin D or if you need help getting more
A close-up of a vitamin D capsule

It’s not always easy or feasible to consume a well-balanced and varied diet. Between juggling a busy schedule with minimal time for healthy food preparation, food allergies and intolerances, dietary preferences, and cultural eating habits, many of us fall short of meeting the nutritional recommendations for several key vitamins and minerals. Even if you cook at home and try to eat a healthy diet, you may be deficient in certain micronutrients because some essential vitamins and minerals are only found in a few food sources or are only present in low concentrations.
Vitamin D is a prime example of a vital nutrient that is not found in many common foods in the standard American diet, nor is it necessarily well absorbed when consumed in food sources. Rather, exposure of the skin to sunlight is the primary means by which the body’s vitamin D levels are increased, as exposure to UVB rays stimulates the production of vitamin D.
However, as the hours of daylight dwindle in the winter and the sun becomes less intense, it becomes increasingly difficult to meet your vitamin D needs. Because vitamin D plays several key physiological roles, it may be advisable to take vitamin D supplements. Keep reading for our helpful primer on the functions and benefits of vitamin D, foods high in vitamin D, and whether vitamin D supplementation may be useful.

What is vitamin D?
Along with vitamins A, E, and K, vitamin D is a fat-soluble vitamin, which means it's stored in the body rather than excreted like vitamins C and B vitamins. However, unlike any other vitamin, vitamin D is actually a steroid hormone produced from cholesterol when skin cells are exposed to UVB rays. In addition to the endogenous production of vitamin D, there are two different dietary forms of the nutrient:

Read more